Cortrosyn Stimulation
Additional Codes
LAB9537
Performing Laboratory
MBMC Main Laboratory
Methodology
Electro-Chemiluminescent Immunoassay (ECLIA)
Specimen Requirements
Specimen Type: Plasma
Container/Tube: Mint-green top (lithium heparin gel)
Specimen Volume: Full tube
Collection Information:
1. Draw baseline specimen before administration of Cortrosyn.
2. Administer Cortrosyn.
2. Draw additional specimens at 30-, and 60-minutes post dose.
3. Label specimens appropriately (corresponding draw times.)
4. Send all specimens to the laboratory together.
Note: Draw times are required on each specimen.
Specimen Transport Temperature
Ambient
Day(s) Test Set Up
Monday through Sunday
Turnaround Time:
STAT: 1 hour after receipt in laboratory
Routine: within 4 hours
Reference Values
Interpretive Data
Reference Values
Cortisol cutoff of 14-15 ug/dL for cortrosyn stimulation testing.
Lack of normal response can be seen in both primary and secondary adrenal failure. Some patients with secondary adrenal failure have normal response to cortrosyn. If pituitary disease is known or strongly suspected e.g. after pituitary surgery), the cortrosyn test alone should not be relied on to exclude adrenal failure.
Literature References:
- Javorsky BR, Raff H, Carroll TB, et al. New cutoffs for the biochemical diagnosis of adrenal insufficiency after ACTH stimulation using specific cortisol assays. J Endocr Soc. 2021;5(4):bvab022.
- Carson JLP and Gronowski AM. New cutoffs for the biochemical diagnosis of Adrenal insufficiency after ACTH stimulation using specific cortisol assays. J. Endocrine Soc 2021;5:1-2.
Current interpret data was last revised 08/12/24
Test Classification and CPT Coding
Test Classification:
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer’s instructions.
CPT Code:
80400-ACTH stimulation panel for adrenal insufficiency
82533 x 2-Cortisol
Profile Information
Includes baseline Cortisol and 2 additional, post dose