Sign in →

NT-Pro B type Natriuretic Peptide (BNP)

Additional Codes

LAB5728

Performing Laboratory

MBMC Main Laboratory

Methodology

Electro-Chemiluminescent Immunoassay (ECLIA)

Specimen Requirements

Specimen Type: Plasma

Container/Tube:  Mint-green top (lithium heparin gel)
Alternative Container/ Tube: Pearl-top (EDTA) tube

Specimen Volume: Full tube

 

Collection Instructions:

1.  Gel tubes should be centrifuged within 2 hours of collection.

2. Lavendar top tube (no gel) should be centrifuged and aliquoted within 2 hours of collection.

Specimen Transport Temperature

Ambient

Day(s) Test Set Up

Monday through Sunday

Turnaround Time:
STAT: 1 hour after receipt in laboratory
Routine: within 4 hours

Reference Values

0-75 yrs:  0-300 pg/mL

>75 yrs:  0-450 pg/mL

 

Interpretation Data:

Dyspnea in Acute Care Setting

 

All ages:      < 300 pg/mL, acute heart failure unlikely

 

<50 yrs:       ≥ 300 pg/mL and ≤ 450 pg/mL, further investigation warranted

 

                     > 450 pg/mL, acute heart failure likely

 

50-74 yrs:    ≥ 300 and ≤ 900 pg/mL, further investigation warranted

 

                     > 900 pg/mL, acute heart failure likely

 

≥ 75 yrs:      450-1800 pg/mL, further investigation warranted

 

                     > 1800 pg/mL, acute heart failure likely

                             

Non-acute Setting

 

<75 yrs:       < 125 pg/mL, rules out heart failure

                     ≥ 125 pg/mL, further investigation warranted

 

≥ 75 yrs:       < 450 pg/mL, rules out heart failure

                      ≥ 450 pg/mL, further investigation warranted

                             

Knowledge of each individual patient’s NT-proBNP range may be more useful than using similar cut-points for every patient. Please note that marked elevations in NT-proBNP levels may be observed in states other than left ventricular congestive failure, including: acute coronary syndromes, right heart strain/failure (including pulmonary embolism and cor pulmonale), critical illness, renal failure, as well as increasing with advancing age.

 

References: Januzzi JL et.al.  Eur Heart J. 2006: 27: 330-337.

Troughton RW, Richards AM. J AM Coll Cardiol: Cardiovasc Imag. 2009; 2: 216-225.

Test Classification and CPT Coding

 

Test Classification:This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer’s instructions.

 

CPT Code:

83880

Stability

5 days Refrigerated