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Histamine Release (Chronic Urticaria)

Additional Codes

LAB7133

Alternative Name(s)

Anti-IgE Receptor,Chronic Urticaria,FCER1, Chronic Urticaria,FC Epsilon Receptor Antibody,CU (Chronic Urticaria)

Performing Laboratory

Quest Diagnostics Nichols Institute - San Juan Capistrano, CA

Methodology

Cell Culture (CC) • Immunoassay (IA)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes

Specimen Requirements

Preferred Specimen(s)

1.5 mL serum collected in a red-top tube (no gel)

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 7 days
  • Refrigerated: 7 days
  • Frozen: 30 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Icteric • Specimen other than serum • Serum Separator Tube (SST®)

Day(s) Test Set Up

Tues, Thurs a.m.; Results available 3-7 days

Test Classification and CPT Coding

86343

Clinical Significance

Histamine Release (Chronic Urticaria) - Chronic Urticaria (CU) is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with CU, and anti IgE antibody has been identified in another 5%-10%.

Patient Preparation

Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw

Reference Range

<16 %