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HelpAcetylcholine Receptor Modulating Antibody
Additional Codes
LAB837
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
Methodology
Radiobinding Assay
Specimen Requirements
Specimen Type:Serum
Container/Tube: Red
Specimen Volume: 1 mL serum (1 Full tube)
Specimen Minimum Volume: 0.3 mL serum
Specimen Transport Temperature
Ambient
Day(s) Test Set Up
Set up: Sun, Tues, Thurs; Report available: 5-7 days
Test Classification and CPT Coding
83519
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 1 year
Limitations
Antibodies may not be found in congenital myasthenia.
Clinical Significance
Myasthenia gravis (MG) is a neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. Modulating Antibody to AChR causes weakness by inhibiting or modulating binding to the receptors.