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HelpHistone Antibodies
Additional Codes
LAB5075
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
Methodology
Enzyme Immunoassay (EIA)
Specimen Requirements
Specimen Type: Serum
Container/Tube: Gold top tube
Specimen Volume: 1 mL serum (1 Full tube)
Specimen Minimum Volume: 0.5 mL serum
Alternative Container/Tube: Red top tube
Specimen Transport Temperature
Refrigerated (cold packs)
Day(s) Test Set Up
Set up: Tues, Thurs, Sat; Report available: 4-5 days
CPT Code
83516
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 14 days
- Frozen: 30 days
Patient Preparation
Overnight fasting preferred
Reference Range(s)
| Value | Explanation of Results |
| <1.0 | Negative |
| 1.0-1.5 | Weak Positive |
| 1.6-2.5 | Moderate Positive |
| >2.5 | Strong Positive |
Clinical Significance
Histone Antibodies - Histone antibody is present in 80-95% of patients with drug-induced Systemic Lupus Erythematosus (SLE), 20-50% of patients with idiopathic SLE, and infrequently in patients with other autoimmune connective tissue diseases.