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Chronic Lymphocytic Leukemia (CLL) Panel, CLL Panel (+12, p53, D13s319, ATM)

Additional Codes

LAB9510

Performing Laboratory

GenPath/Bio-Reference Laboratories, Inc.

Methodology

FISH

Trisomy 12 (+12) is found in about 20% of CLL/SLL cases and is usually associated with an unfavorable response to chemotherapy and a predominantly unmutated IgVH gene status. D13s319- Deletions involving 13q14 are detectable by FISH in approximately 50% of persons with CLL. This deletion is associated with a favorable clinical outcome. ATM (11q22) mutations of the ataxia-telangiectasia gene are seen in 10% to 20% of B-cell CLL and are associated with a relatively aggressive disease course and poorer prognosis. p53 (17p13) monosomy is usually associated with an unfavorable response to chemotherapy.

Specimen Requirements

Specimen must arrive at GenPath within 24 hours of collection.

 

Specimen source is required.

 

Submit only 1 of the following specimens.

 

Specimen Type: Bone marrow

Container/Tube: Green top (heparin) or Lavender top (EDTA)

Specimen Volume: 0.5 mL

 

Specimen Type: Whole blood

Container/Tube: Green top (heparin) or Lavender top (EDTA)

Specimen Volume: 5 mL

 

Specimen Type: Fresh tissue

Container/Tube: Container with RPMI media

Specimen Volume: Adequate amount

 

Alternate

Specimen Type: Non-decalcified paraffin-embedded tissue block

Specimen Volume: Adequate amount

 

 

Causes for Specimen Rejection:

-No patient ID on specimen

-Patient ID on specimen and requisition doesn’t match

-Incorrect fixative (tube/solution)

-Specimen without GenPath/Bio-Reference requisition

-Frozen specimen

Specimen Transport Temperature

Refrigerate <24 hours/Ambient NO/Frozen NO

Day(s) Test Set Up

Monday through Saturday

Turnaround Time:

24 to 72 hours

Test Classification and CPT Coding

88367 x 1

88373 x 3