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Help19911 A→G Mutation Analysis
Additional Codes
LAB3513
Clinical Significance
This test can be used to detect the 19911A→G polymorphism in the prothrombin (Factor II) gene which may modulate the risk of deep vein thrombosis in patients with the G20210A mutation
Methodology
Capillary Electrophoresis • Fluorescence Detection • Polymerase Chain Reaction Amplification • Single Nucleotide Extension
Reference Range(s)
See Laboratory Report
Preferred Specimen(s)
5 mL whole blood collected in an EDTA (lavender-top) tube - send original tube of blood
Alternative Specimen(s)
Whole blood collected in: ACD solution A or B (yellow-top) tube, lithium heparin (green-top) tube or sodium heparin (green-top) tube
Minimum Volume
3 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable
Setup Schedule
Set up: Thur a.m.; Report available: 8-14 days
Reject Criteria
Received frozen
CPT Code
81400 - This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.