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ABPA (Allergic Bronchopulmonary Aspergillosis) Cascade

Methodology

IgE Total: Electrochemiluminescence immunoassay (ECLIA) 
Asper fum IgE: Fluorescence Enzyme Immunoassay (FEIA) 
Asper fum IgG: Fluorescence Enzyme Immunoassay (FEIA)

Specimen Requirements

Specimen Type: Blood

Container/Tube

Preferred: Gold/Red SST Vacutainer®

Acceptable: Plain red-top vacutainer ®

Collection Volume: 3.0 mL 

Day(s) Test Set Up

IgE Total: Monday-Sunday

Aspergillus fum, IgE specific: Monday-Friday

Aspergillus fum, IgG: Monday-Saturday

Reference Values

IgE Total

<1 year:

<50.0 IUnits/mL

1 year-3 years:

<100.0 IUnits/mL

3 years -5 years:

<300.0 IUnits/mL

5 years -8 years:

<400.0 IUnits/mL

8 years -16 years:

<600.0 IUnits/mL

16 years -18 years:

<500.0 IUnits/mL

>18 years:

<100.0 IUnits/mL

Aspergillus fumigatus IgE (M3)

≤0.34 kUnits/L

Reference values apply to all ages.

Aspergillus fumigatus IgG

<4 years:

None established

≥ 4 years:

≤ 102 mg/L

Test Classification and CPT Coding

82785 - IgE

86003 - Aspergillus fum IgE (if appropriate)

86606 - Aspergillus fum IgG (if appropriate

Algorithm

Testing Algorithm: if Immunoglobulin E (IgE) is >417.00 IUnits/mL, then 'Aspergillus fumigatus, IgE Specific (M3)' will be performed at an addition charge. If the 'Aspergillus fumigatus IgE' is positive (>0.35 kUnits/L), then 'Aspergillus fumigatus IgG Antibodies' will be sent to outside reference lab at an additional charge.