Test Code LAB489 Protein C Activity, Plasma

Additional Codes

LAB489

Methodology

Chromogenic

Literature References:

HemosIL Protein C (pn20300500) package insert issued 01/2007, Instrumentation Laboratory.

Performing Laboratory

Barnes-Jewish Hospital Laboratory

Specimen Requirements

Specimen Type: Blood

Container/Tube: Light-blue top (citrate)
Specimen Volume: Full tube
Specimen Minimum Volume: 1 Full tube
Collection Instructions:

Draw a discard blue top tube prior to drawing a light-blue top (citrated) tube if using a Winged Infusion Set. Discard tube should be under filled and discarded.
Clotted blood or an insufficient specimen is not acceptable.
Avoid phlebotomy techniques which cause hemolysis and heparin contamination.
Follow nursing policy on volume of blood to discard prior to collecting blood from indwelling heparinized catheters.

Analyte Stability:

4 hours at 18° C to 24° C.

Platelet-free plasma can be frozen at -20 for transport on dry ice up to 72 hours
or stored 6 months at -70° C.

Additional Information: If the patient is a hospital patient and the hematocrit is >55%, call Barnes-Jewish Hematology Laboratory at 314-362-5203 for instructions.

Specimen Transport Temperature

Ambient Yes/Refrigerate NO/Frozen Yes

Reference Values

60%-150%
Numerous drugs and clinical conditions affect the plasma concentration of the protein.

Literature References:

1. Griffin JH, Evatt B, Zimmerman TS, et al. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981;68:1370-3.

2. Comp PC, Nixon RR, Esmon CT. Determination of functional levels of protein C, an antithrombotic protein, using thrombin-thrombomodulin complex. Blood 1984;63:15-21.

Day(s) Test Set Up

Monday, Wednesday, and Friday

Cut-off time: 0700

Turnaround Time:

STAT: not available

Routine: results available the day of testing

Test Classification and CPT Coding

85303

Additional Information

For BJH Laboratory Use Only

Analyte Stability:
4 hours at 18^o C to 24^o C.