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Thiopurine Metabolites (TPMT)

Additional Codes

LAB5349

Performing Laboratory

PROMETHEUS Laboratories Inc.

Methodology

PROMETHEUS Thiopurine Metabolites testing assists physicians in optimizing ongoing dosing of thiopurine immunosuppressant therapy to reach and maintain therapeutic goal. Thiopurine metabolite testing also helps to identify drug metabolite levels that may lead to toxicity and some of the reasons for treatment failure.

A quantitative evaluation of 6-TGN (thioguanine nucleotide) and 6-MMPN (methyl mercaptopurine nucleotide)

Specimen Requirements

Specimen Type: Whole blood

Container/Tube: Lavender top (EDTA)

Specimen Volume: 5 mL

Specimen Transport Temperature

Refrigerate <8 days/Ambient <24 hours OK/Frozen NO

Day(s) Test Set Up

Turnaround Time:

3 business days from date of receipt.

Reference Values

6-TGN: 230-400 pmole/8 x 108 RBC

6-MMPN: <5,700 pmole/8 x 108 RBC

Test Classification and CPT Coding

824542