Thiopurine Metabolites (TPMT)
Additional Codes
LAB5349
Performing Laboratory
PROMETHEUS Laboratories Inc.
Methodology
PROMETHEUS Thiopurine Metabolites testing assists physicians in optimizing ongoing dosing of thiopurine immunosuppressant therapy to reach and maintain therapeutic goal. Thiopurine metabolite testing also helps to identify drug metabolite levels that may lead to toxicity and some of the reasons for treatment failure.
A quantitative evaluation of 6-TGN (thioguanine nucleotide) and 6-MMPN (methyl mercaptopurine nucleotide)
Specimen Requirements
Specimen Type: Whole blood
Container/Tube: Lavender top (EDTA)
Specimen Volume: 5 mL
Specimen Transport Temperature
Refrigerate <8 days/Ambient <24 hours OK/Frozen NO
Day(s) Test Set Up
Turnaround Time:
3 business days from date of receipt.
Reference Values
6-TGN: 230-400 pmole/8 x 108 RBC
6-MMPN: <5,700 pmole/8 x 108 RBC
Test Classification and CPT Coding
824542