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Test Code LAB6464 Extractable Nuclear Antigens (ENA) Screen, Serum

Additional Codes

LAB6464

Methodology

Multiplex Flow Immunoassay

Testing Algorithm:

If ENA screen is positive, Anti-RNP Antibody; Anti-Sm Antibody, Anti-SSA/Ro Antibody; Anti-SSB/La Antibody; Anti-Scl-70 Antibody; and Anti-Jo-1 Antibody will be performed at an additional charge.

Literature Reference:

Package Insert: BioPlex 2200 ANA Screen kit. BioRad Laboratories, Inc. 03/2012

Performing Laboratory

Barnes-Jewish Hospital Laboratory

Specimen Requirements

Specimen Type: Serum

Container/Tube: Plain red top, Red/grey SST or Gold SST

Specimen Volume: Full tube

 

Specimen Transport Temperature

Ambient

Reference Values

Negative

Positive screens will be reflexed to specific testing for antibodies against the following antigens: Jo-1 Ab, RNP Ab, Scl-70 Ab, Sm Ab, SS-A/Ro Ab and SS-B/La Ab. Further testing for dsDNA, Centromere, and Ribosomal P antibodies is suggested in patient with a positive screen and negative specific antibodies.

Literature References:

Package Insert: BioPlex 2200 ANA Screen kit. BioRad Laboratories, Inc. 03/2012

Day(s) Test Set Up

Monday through Sunday
Cut-off time: 1000

Turnaround Time:
STAT: not available
Routine: results available the day of testing

Test Classification and CPT Coding

86235-ENA antibody
86235 x 6-ENA antibody (if appropriate)

Additional Information

For BJH Laboratory Use Only
Analyte Stability:

See Analyte Stability Chart

Laboratory Processing Instructions:
Test performed in BJH Core Lab. Processed by automated line and aliquot stored refrigerated for batch analysis. Completed specimens are stored refrigerated for 5 days.

LOINC Code Information

Name LOINC Code
Extractable Nuclear Antigen Screen 47383-5
Jo-1 Antibody 5234-0
RNP Antibody 51928-0
Scl-70 Antibody 5348-8
Smith Antibody 43182-5
Sjogren's Syndrome A Antibody 33569-5
Sjogren's Syndrome B Antibody  45142-7