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HelpCeliac PLUS
Additional Codes
LAB7835
Performing Laboratory
PROMETHEUS Laboratories Inc.
Methodology
PROMETHEUS Celiac PLUS includes both PROMETHEUS Celiac Serology and PROMETHEUS Celiac Genetics.
PROMETHEUS Celiac Serology is a comprehensive serum antibody profile. By combining important serologic markers for diagnosing celiac disease and utilizing a 5-marker panel including deamidated gliadin peptide antibodies IgA and IgG, this test offers consistent results from a recognized leader in celiac testing.
PROMETHEUS Celiac Genetics analyzes a patient’s genetic profile for genes specifically associated with celiac disease.
Advanced high-resolution DNA probe analysis of HLA-DQ haplotypes allow for disease risk stratification depending upon which HLA genes are detected. Also, testing can predict with a 95% to 100% negative predictive value (NPV) that the patient will not develop celiac disease if HLA-DQ2 and HLA-DQ8 haplotypes are not present.
Specimen Requirements
Whole blood and serum are required.
Specimen Type: Whole blood
Container/Tube: Lavender top (EDTA)
Specimen Volume: 5 mL
Specimen Type: Serum
Container/Tube: Serum gel or red top
Specimen Volume: 2 mL
Specimen Transport Temperature
Ambient <7 days/Refrigerated <14 days OK
Day(s) Test Set Up
Turnaround Time:3 business days from date of receipt.
Reference Values
Deamidated gliadin peptide antibody IgG ELISA: <4.9 EU/mL
Deamidated gliadin peptide antibody IgA ELISA: <6.1 EU/mL
Anti-human tTG IgA ELISA: <10.3 U/mL
Anti-endomysial IgA IFA: Negative
Total serum IgA:
< 3 years: 8-220 mg/dL
3-13 years: 41-395 mg/dL
>13 years: 44-441 mg/dL
HLA-DQ2/DQ8: Not Detected (Allele frequency varies by ethnic population)
Test Classification and CPT Coding
81382 (x2), 82784, 86231, 86258 (x2), 86364