Home
HelpCeliac PLUS
Additional Codes
LAB7835
Performing Laboratory
PROMETHEUS Laboratories Inc.
Methodology
PROMETHEUS Celiac PLUS includes both PROMETHEUS Celiac Serology and PROMETHEUS Celiac Genetics.
PROMETHEUS Celiac Serology is a comprehensive serum antibody profile. By combining important serologic markers for diagnosing celiac disease and utilizing a 5-marker panel including deamidated gliadin peptide antibodies IgA and IgG, this test offers consistent results from a recognized leader in celiac testing.
PROMETHEUS Celiac Genetics analyzes a patient’s genetic profile for genes specifically associated with celiac disease.
Advanced high-resolution DNA probe analysis of HLA-DQ haplotypes allow for disease risk stratification depending upon which HLA genes are detected. Also, testing can predict with a 95% to 100% negative predictive value (NPV) that the patient will not develop celiac disease if HLA-DQ2 and HLA-DQ8 haplotypes are not present.
Specimen Requirements
Whole blood and serum are required.
Specimen Type: Whole blood
Container/Tube: Lavender top (EDTA)
Specimen Volume: 5 mL
Specimen Type: Serum
Container/Tube: Serum gel or red top
Specimen Volume: 2 mL
Specimen Transport Temperature
Ambient <7 days/Refrigerated <14 days OK
Do not freeze
Day(s) Test Set Up
Turnaround Time: 4 business days from date of receipt.
Reference Values
Deamidated gliadin peptide antibody IgG : <20 CU
Deamidated gliadin peptide antibody IgA : <20 CU
Anti-human tTG IgA : <20 CU
Anti-endomysial IgA : Negative
Total serum IgA:
4-9 years: 27-305 mg/dL
10-19 years: 53-348 mg/dL
>19 years: 85-499 mg/dL
HLA-DQ2/DQ8: Not Detected (Allele frequency varies by ethnic population)
Test Classification and CPT Coding
81382 (x2), 82784, 86231, 86258 (x2), 86364