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Test Code PQNRU Porphyrins, Quantitative, Random, Urine

Additional Codes

LAB8478

Reporting Name

Porphyrins, QN, Random, U

Useful For

Preferred test to begin assessment for congenital erythropoietic porphyria and porphyria cutanea tarda and during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria when specimen transport will not exceed 72 hours

 

This test is not useful for the diagnosis of conjugated or unconjugated hyperbilirubinemia syndromes such as Dubin Johnson syndrome or Rotor syndrome.

Testing Algorithm

The following algorithms are available:

-Porphyria (Acute) Testing Algorithm

-Porphyria (Cutaneous) Testing Algorithm

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Ordering Guidance


This random urine test should be ordered when the specimen will be received at Mayo Clinic Laboratories within 72 hours. If transportation may take longer than 72 hours, order both PQNU / Porphyrins, Quantitative, 24 Hour, Urine and ALAUR / Aminolevulinic Acid, Urine and follow collection guidelines.



Shipping Instructions


Ship specimen in amber bottle to protect from light.



Necessary Information


Include a list of medications the patient is currently taking.



Specimen Required


Patient Preparation: For at least 24 hours before specimen collection, patient must not consume any alcohol.

Supplies: Urine Container - Amber, 60 mL (T596)

Container/Tube: 60-mL Amber urine container

Specimen Volume: 20 to 50 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative3. Specimens should be protected from light and frozen immediately following collection.


Specimen Minimum Volume

15 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen 72 hours LIGHT PROTECTED

Reference Values

Uroporphyrin, Octa: ≤3.1 mcmol/mol creatinine

Heptacarboxylporphyrins: ≤0.9 mcmol/mol creatinine

Hexacarboxylporphyrins: ≤0.3 mcmol/mol creatinine

Pentacarboxylporphyrins: ≤1.2 mcmol/mol creatinine

Coproporphyrin, Tetra: ≤25.0 mcmol/mol creatinine

Porphobilinogen: ≤0.2 mmol/mol creatinine

Aminolevulinic Acid: ≤ 2.3 mmol/mol creatinine

Day(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84110-Porphobilinogen, quantitative

84120-Porphyrins, quantitation and fractionation

82135- ALA Delta Random Urine

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PQNRU Porphyrins, QN, Random, U 93707-8

 

Result ID Test Result Name Result LOINC Value
32332 Uroporphyrin, Octa 25166-0
32333 Heptacarboxylporphyrins 34314-5
32334 Hexacarboxylporphyrins 96795-0
32335 Pentacarboxylporphyrins 34352-5
32336 Coproporphyrin, Tetra 25167-8
32337 Porphobilinogen 2811-8
623039 Aminolevulinic Acid, U 39782-8
32338 Interpretation 49291-8
623040 Reviewed By 18771-6

Report Available

2 to 4 days

Method Name

High-Performance Liquid Chromatography (HPLC) with Fluorometric Detection/Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)